Showing posts with label genetics. Show all posts
Showing posts with label genetics. Show all posts

Monday, February 18, 2013

Unexpected links

A few days ago, a friendly reader of my blog sent me a link to a list of online genealogical resources [here]. I replied that an all-important resource was glossed over in the list. Genealogical research is often dominated by black swan happenings, in the sense suggested by Nassim Nicholas Taieb: that's to say, totally unexpected events that upset the nice and tidy little applecart upon which the researcher had been basing his beliefs.


The biggest black swan that has alighted upon my genealogical research over recent months concerned my Pickering relatives (through the family of my paternal grandmother). On 3 March 2012, my bucolic blog post entitled Vicar's garden [display] evoked the rural existence of our forebear Henry Latton [1737-1798],  the vicar of Woodhorn in Northumberland. I ended that blog post by saying that the vicar would have surely disapproved of my science-based atheism.


Be that as it may, my dear great-great-great-great-grandfather did not deserve to be murdered by bandits while returning from an afternoon of betting on the horses at Newbiggin-by-the-Sea.

Six months after having evoked this Latton ancestor, I got an unexpected e-mail from an unknown Englishman named Latton who told me an amazing tale. He alleged that his own grandfather, known to him as John Edward Latton, was in fact the same individual designated in my document They Sought the Last of Lands [display] as John Edward Latton Pickering [1851-1926]. In other words, my correspondent was saying that we had a skeleton in one of our family-history closets: a respected Londoner (archivist at the Inner Temple law library) who had invented a new name for himself (borrowed from our Latton ancestors) and forged a marriage certificate enabling him to become a full-fledged bigamist and raise a second family in parallel to his first one. Needless to say, I've got over the surprise by now, and I'm looking forward to meeting up with my new English cousin when he drops in at Gamone with his wife this summer.

That wasn't the only recent black swan. In April 2012, I became really excited about a possible research avenue aimed at elucidating the mystery of the Norman origins of the Skeffington family. In blog posts entitled Patriarch [display] and Skeffington/Verdun links [display], I evoked the identity of a celebrated Norman family with close attachments to the Leicestershire village of Skeffington at the time of the Conquest. I concluded my first blog post, on 27 April 2012, as follows:
Another fascinating question emerges. Is it thinkable that our patriarch Bertram de Verdun might have descendants today in France and elsewhere? Well, to put it mildly, judging from what I've seen through a rapid visit to the Genea website, it would appear that the community of my so-called "genetic cousins" includes many present-day members of the old nobility of Normandy and France.

When I asked that "fascinating question", I had not yet started to look around in France with the aim of contacting living de Verdun descendants. From this point on in the present blog post, I'm obliged to be deliberately vague, because I wish to avoid mentioning names that would be picked up by search engines. Let me explain in roundabout terms that, in April 2011, French police had come upon a nasty crime scene in the city whose mayor was our present prime minister, Jean-Marc Ayrault. They unearthed the bodies of a mother and her four teenage kids. As for the father, he has totally disappeared. Most people consider that the father—whom I shall refer to as X—is indeed the culprit. On the other hand, X's sister is convinced that her brother never murdered his wife and children. In the ongoing crusade aimed at protecting the honor of her brother, this determined lady is assisted by her husband... who happens to bear exactly the same ancient Norman name as the Conqueror's companion associated with the Leicestershire village of Skeffington, evoked in the "fascinating question" that I have just quoted. For all I know, X's brother-in-law could well be a direct descendant of the 11th-century personage who interests me. Naturally, in the context of my Skeffington research, I would be interested in the possibility of examining a description of the Y chromosomes of this present-day Frenchman. For the moment, though, such a request for DNA data would be out of place, and unwise.

POST SCRIPTUM: In the wake of my initial enthusiasm about the possibility that Bertram de Verdun might have been the "elusive patriarch" whom I've been seeking for so long, I now believe that this was a false track. Click here to download the latest version of chapter 1 of my slowly-emerging Skeffington One-Name Study.

Friday, September 7, 2012

Junk's not junk

For ages, it has been said that humans use only a small percentage of their cerebral potential. Personally, I've always been wary of this kind of evaluation. The experimental evidence for such a conclusion is obscure, to say the least. What would it mean, at a practical level, if my cerebral performances were suddenly doubled, say? Would I understand twice as many things as I did previously? Would I have a vision of our human existence that was twice as deep as my old way of looking at things? Would I be capable of thinking twice as rapidly as I used to? Would I be able to master new fields of learning? Would I now have a clear perception of things that once appeared fuzzy in my mind? Would I be clearly conscious of the fact that I was twice as smart as I used to be? Frankly, I've always imagined all that extra yet-unused brainpower as akin to the legendary multiple lives of a cat. It sounds like a great idea... up until you try to imagine what it might mean in practice.

More recently, I've often been similarly wary, indeed stupefied, when I've heard geneticists talk of so-called junk DNA. The idea is that only some 2 per cent of our precious genetic heritage plays an essential role in the synthesis of proteins and operational cells and organs. The remaining 98 per cent would appear to be biological "dark matter" that simply comes along for the ride, in an almost parasitical fashion.

Once upon a time, when scientists told us that the human body was largely composed of water, I used to wonder whether it might be possible to "dry out" a human being, by removing magically all this surplus wetness. Would the waterless creature work just as well? Or would he simply shrivel up and die like a fish discarded on a sunny riverbank? In a similar way, I wondered naively about all that junk stuff that I was carrying around with me. If it were completely useless in my survival, then we might imagine a zapping device capable of eliminating everything that wasn't essential. Normally, after being zapped, I would be reduced to a dwarf, with only 2 percent of my original volume, but I would remain just as smart as before... or even much smarter, if I decided to combine the junk-DNA-zapping with a foolproof method for gaining control of all my unused brainpower. I would be transformed into a mighty midget! As Hamlet said:
I could be bounded in a nutshell, and count myself a king of infinite space, were it not that I have bad dreams.
We adepts of genealogical research have always been stalwart admirers of junk DNA. Funnily enough, although specialists affirmed that all this vast quantity of code achieved nothing of a useful nature, it was nevertheless the object of mutations. And the analysis of such mutations in Y-chromosomes has enabled us to trace paternal lineages. So, the junk hasn't been as totally junky as you might imagine. For example, if ever I were able to discover the identity of the first fellow in England who procreated dozens of generations of descendants named Skeffington (Skevington, Skivington, Skyvington, etc), then my junk DNA would be far more precious, for me, than all the crown jewels in the Tower of London.

Meanwhile, researchers concerned with the human genome have just announced that it is high time for us to realize that so-called junk DNA is anything but that. These researchers have been participating in a huge research project known as Encode: a consortium, based at the University of Santa Cruz in California, that is building a huge databse of the various bits and pieces of the genome.


DNA strings that don't code the synthesis of proteins take care of a multitude of necessary behind-the-scenes activities such as switching genes on or off, and regulating the context in which genes carry out their functions. Suggesting that DNA segments are "junk" simply because they don't have a star role in the coding of proteins is as silly as saying, for example, that the fabulous Avatar movie was created solely by a single director, or a pair of actors, and that all the background support was of no importance.


I liked the comments of an observer who referred to research in genetics by means of a sporting metaphor. "We're still in the warm-up, the first couple of miles of this marathon."

Friday, August 31, 2012

Opening chapter of Skeffington study

I've more-or-less terminated the opening chapter of my Skeffington One-Name Study, entitled Elusive patriarch [download], dealing with the half-century that followed the Norman Conquest in Leicestershire, in the vicinity of the village of Skeffington.


As the title of this opening chapter suggests, I haven't been able to track down and identify the patriarch of the Skeffington family in England. So, you might say that the hero of my document is totally absent. On the other hand, as I've often suggested, the widespread adoption of genealogical genetics (Y-chromosome profiles) could well add totally new dimensions to this quest. For the moment, I seem to have no potential relatives whatsoever in the Y-chromosome database, so the current score of my Skeffington matching is a huge zero. In fact, the match hasn't even got under way yet, since I'm still the sole player on the field. My chapter 1 might become interesting in the future, for certain small groups of readers, when the techniques of genealogical genetics have become commonplace.

Wednesday, August 15, 2012

What, no rock 'n' roll in the caves?

Svante Pääbo, 57, is a Swedish geneticist at the Max Planck Institute for Evolutionary Anthropology in Leipzig.


In my blog post of 26 December 2010 entitled Prehistoric encounters [display], I mentioned the existence in Siberia, 30 millennia ago, of humanoid creatures—on an evolutionary par with Neanderthals—known as Denisovans. It was Pääbo's team that revealed the existence of these people, in March 2010, using mtDNA [mitochondrial DNA] that was lurking in a single Denisovan finger bone.

Two months later, Pääbo's team published a draft sequence of the Neanderthal genome. Noticing that a certain quantity of DNA is common to both Neanderthals and modern humans whose ancestors had moved beyond Africa, Pääbo's team announced that it was likely that a certain degree of sexual promiscuity had characterized relationships between Neanderthals and humans in the course of their many millennia together, side by side, on the planet Earth.

                          — photo Jochen Tack/Alamy

That idea doesn't surprise me at all. On the contrary. I can well imagine a randy Cro-Magnon gentleman running into a horny Neanderthal lady, on his way home from the hunt at the end of a wintry afternoon, and paraphrasing in his imagination the well-known Canada Dry words: "It looks like whisky, smells like whisky, and tastes like whisky."


I imagine myself in the Cro-Magnon's place, on the horns of a dilemma. Regardless of the respective species (or races, or whatever) of the Neanderthal wench and me, I would have surely decided, there and then, that a little bit of Guinness would be good for me... and for her, too, no doubt.

Now, I learn today from The Guardian [access] that certain sourpuss scientists are abandoning this delightful idea of intertribal rock 'n' roll. They suggest that the DNA stuff shared by Neanderthals and us humans was surely a remnant of code that existed already in our most recent common ancestor, half a million years ago, before we had differentiated into Neanderthals and humans. Their reasoning is perfectly plausible, but it strikes me as somewhat puritanical. I far prefer the friendly idea of a whole lotta prehistoric shakin' goin' on.

Monday, June 11, 2012

Dogs in God's city

Dogs, in the context of conventional religions, have often had a hard time. An antiquated version of Revelations, on the very last page of my ugly King James Bible, states:
I am Alpha and Omega, the beginning and the end, the first and the last.
Blessed are they that do his commandments, that they may have right to the tree of life, and may enter in through the gates into the city.
For without are dogs, and sorcerers, and whoremongers, and murderers, and idolaters, and whosoever loveth and maketh a lie.
So, in a heavenly context, dogs would be "without" (along with perverts, sorcerers, fornicators, murderers and idolaters)... just like the body of Jesus with respect to his tomb in Jerusalem. [One of my favorite jokes. A pious lady visiting the ornate tomb of the Holy Sepulcher asks her guide, a priest: "Is there anyone inside?" Priest: "Lady, if He's in, then I'm out."]

All this Biblical stuff is most smelly dogshit.

I remain astonished—as I said in my blog post entitled Is the Bible good English literature? [display]—that a great evolutionary zoologist such as Richard Dawkins might seriously appreciate the alleged literary qualities of this kind of antiquated twaddle.

Within Buddhism, of course, the situation for dogs is not much better. If I understand correctly, Buddhists place dogs at the extreme lower end of the spiritual scale (or whatever it might be called). I evoked this horrifying canine disparagement in my blog post entitled Tea for two expats [display].

In God's Own City, Jerusalem, the authorities are fed up with those nice droppings of angels, commonly referred to as dog shit. And they plan to use a genetics database to identify culprits.

Translation: "If you didn't clean it up, then it's you who left the shit."

This means that all dogs in Jerusalem will be required to supply their DNA specifications (a fine idea in the perspective of future yet-undefined biological research). Then a squad of turd inspectors (employment conditions and salaries not yet specified) will spend their working days gathering biological data on the Holy City's latest dog shit. And dog-owners will be fined whenever their animals are found to have defecated on the municipal territory.

I laugh out loud at the image of Israeli turd inspectors sticking their noses inadvertently and unknowingly into UFOs [unidentified fallen objects] such as non-canine excrement (including human shit). Within the category of possible turds, we have no theological right to exclude the possibility of authentic angels' poo (bearing small white wings), or even (God be blessed!) a tiny turd or two from the good old Holy Ghost himself. All these possibilities are based, of course, upon the predictions of high-quality Byzantine science.

Wednesday, November 30, 2011

FitzWolf

In a blog post of 9 August 2010 entitled Sophia's future companion at Gamone [display], I explained that the elegant name Fitzroy, which I would give to my young Border Collie a year ago, was in fact the surname of one of my ancient ancestors: a bastard son of King John.


The term Fitz means "son of", and roy is Old French for "king". The bastard Fitz who was my ancestor—often specified as Richard Fitzjohn Chilham—is mentioned briefly in this delightful book:


Well, I often get around to imagining my dog as a descendant, not of a king, but of a wolf. So, I often call him either FitzLoup (in French) or simply FitzWolf. These reveries started recently in my imagination when I thought about an amazing story told by Richard Dawkins in The Ancestor's Tale [pages 29-31] and then repeated in The Greatest Show on Earth [pages 73-76].


It's the story of an experiment carried out by the Soviet scientist Dmitri Belyaev [1917-1985] using a beautiful domestic animal, the Russian Silver Fox, bred for the fur trade.


[First parenthetical remark. What a horrible idea: killing such a glorious animal just to be able to transform its skin and fur into a coat.]

[Second parenthetical remark. The geneticist Belyaev was a man whom we might admire a priori, since he was sacked because he disagreed with the quackery of the Stalinist agronomist Trofim Lysenko.]

Belyaev's experiment was aimed at studying the concept of tameness in successive generations of his foxes. The basic experimental procedure consisted of offering food to fox cubs and trying to fondle them. According to their reactions, the young animals were classed in three categories:

(1) The wildest cubs would either flee or act aggressively, maybe by biting the experimenter's hand.

(2) Certain cubs would accept the food and the experimenter's caresses, but grudgingly, as it were, with no apparent enthusiasm.

(3) The tamest category of cubs would, not only accept the food, but exhibit a positive reaction to the experimenter's caresses, by wagging their tails and crouching down in front of him.

Only fox cubs in this third category would be used for breeding the next generation. And so on…


Not surprisingly, this breeding strategy produced cubs that were tamer and tamer. But the experiments resulted in consequences—we might say side effects—of a totally unexpected kind. The new generations of tame foxes started to look somewhat different to their relatively wilder genetic cousins. In a nutshell, the tame foxes started to look like Border Collies! Truly, it was magic… but simply genetic magic! While the silver foxes were being bred uniquely for tameness, their genes "threw in for free"—as it were—a whole host of genetically-connected features that were apparently linked rigorously with tameness.

Nature speaks to us with her eons of accumulated wisdom: If you want a tame fox, then what we have to offer you is a dog-like fox! Nature might have added: Take it or leave it! Me, I say enthusiastically that I'll take it, because my marvelous tame wolf is Fitzroy… whose fur warms me for a delightful instant when he jumps up onto my knees in front of the fireplace.

Often, I'm overwhelmed when I observe at close range the intense human-like gaze of Fitzroy, which has infinitely more profundity and meaning than the dumb expression of less-introspective animals.


Fitzroy is surely just a few magic chemicals away from being capable of discussing Dawkins with me… but that minor metamorphosis is likely to necessitate a few million years, to say the least, with all the risks of the long road. Frankly, Fitzroy and I tend to agree (not to mention the tacit approval of Sophia) that, for the moment, it's best we stay put.

Saturday, October 22, 2011

What science is saying

These days, the general public is being offered countless presentations of scientific conclusions concerning the origins of human beings. The tone of some of these presentations is so clear, and their contents are so striking, that most people should grasp what is being said, and be impressed by the scope and depth of such explanations. I would imagine that most young people react seriously to such presentations, whereas many adults probably find ways of shielding themselves from the impact of revolutionary facts capable of disturbing them.

Near the start of The Magic of Reality, Richard Dawkins presents readers with a spectacular thought experiment: that's to say, a virtual project carried out, not in a laboratory, but in your imagination. You're asked to stack up portraits of your father, your father's father, your father's father's father, and so on: that's to say, all your paternal male ancestors. The huge stack of images—extending backwards in time—might be laid out on bookshelves, enabling you to browse through them in an orderly fashion to examine the portrait of any specific male ancestor.

If you browsed back to the portrait of your 4,000-greats-grandfather, you would discover a bearded dark-skinned fellow not unlike men you might see today, say, in a Moroccan village. If you browsed back much further, to the portrait of your 50,000-greats-grandfather, you would come upon an individual who looks like the proverbial caveman. Dawkins then asks you to browse all the way back to your 185-million-greats-grandfather. What might he look like? With the help of brilliant illustrations from Dave McKean, Dawkins supplies an answer, which might shock certain readers:

This portrait of a grandpappy is far removed from the typical paintings of distinguished oldtimers in the portrait galleries of aristocratic families. The ancestor who most impressed me was our long-snouted 45-million-greats-grandfather, shown here having a snack:

To appreciate these ancestral illustrations and explanations, you really must get a copy of this splendid Dawkins book, which is packed with all kinds of fascinating tales (including myths) and science stuff.

A few evenings ago, on the Arte TV channel, I watched an interesting documentary on population genetics. Viewers were introduced to the fabulous possibilities of examining DNA specimens to determine the genealogy of various ethnic communities. Personally, I prefer to acquire my knowledge of population genetics and large-scale genealogy through reading books, articles and Internet stuff rather than depending on TV. I would imagine however that this documentary must have been an eye-opener for viewers who were unaware of state-of-the-art findings and thinking in this complex domain.

The subject was tackled in a controversial style (rightly, I believe) by insisting on the fact that the old-fashioned concept of human races is totally rejected by modern research. All human beings who exist today on the planet Earth are the biological descendants of a small group of Africans who were probably similar to the community known today as South African Bushmen. In a sense, therefore, we are all Africans! This poetic declaration charmed 80-year-old Desmond Tutu.

Certain facts are likely to amaze white-skinned Europeans and citizens of the New World, and maybe make us more humble. For example, there is no doubt whatsoever that our prehistoric ancestors were black-skinned, and that our present whiteness is a freakish new-fangled affair brought on by the physiological fact that fairer ex-Africans survived better in cold climates. So, alongside "black is beautiful", we might proclaim that "negro is normal", whereas "white is weird".

These days, research in population genetics is advancing so rapidly that certain major breakthroughs have occurred in the short time since the French TV documentary was completed. For example, there have been amazing revelations concerning the early date at which the ancestors of Australia's Aborigines left Africa. In the 1920s, a lock of hair was taken from an anonymous young Aboriginal male near Kalgoorlie. Well, this DNA specimen was sufficient to enable, recently, an analysis of the subject's genome. And it became obvious that the ancestors of Australia's Aborigines had in fact left Africa at least some 50 millennia ago: that's to say, well before the exodus that gave rise to communities of Homo sapiens in Asia and Europe.

A tribal elder described this DNA-based breakthrough as "just a white-fella story", and said he would continue to believe in the tribe's mythical creation legends.

Saturday, July 30, 2011

Smart boss

At the start of a recent Dilbert strip, I was surprised, indeed intrigued, to find the Pointy-Haired Boss referring to the sophisticated phenomenon of telomeres, which are the repetitive DNA sequences found at both ends of our chromosomes. After all, it was only in 2009 that the Australian-born biologist Elizabeth Blackburn was awarded (along with two colleagues) the Nobel Prize in Physiology or Medicine for the discovery of the way in which telomeres "protect" a chromosome whenever it replicates.

The boss's allusion to "short telomeres" evokes an hypothesis that has become widespread (although not yet fully confirmed) at the level of afflictions such as cancer and aging. The general idea is that a fragment at the extremity of a telomere is "sacrificed" during cell replication, and this insignificant destruction means that relatively important fragments further down the line will not be damaged, as they would be if the protective telomere "cap" were not present. In a healthy individual, this partial destruction of one end of the telomere is harmless, since it can rebuild itself later on. On the other hand, if an individual's telomeres have been reduced to an abnormally short length, then that person is a likely candidate—according to the above-mentioned hypothesis—for cancer and senescence.

I was surprised by the boss's knowledge of modern genetics. I didn't know that a narrow-minded man of his kind would have heard of telemeres. Maybe, if I had the habit of reading popular-science magazines, or stuff about health, I would have realized that telomeres have indeed become a household word. Incidentally, in the remaining frames of the Dilbert strip, the boss informs the job candidate that short telomeres are a sign that the individual in question values work above physical well-being.

[Click the image to access an article that the boss may have read.]

Another thing that intrigues me in this affair is the question of how an ordinary individual might learn that his telomeres are abnormally short. I've had my Y-chromosomes analyzed in a genealogical context [see description], but that trivial operation taught me nothing whatsoever concerning the length of my telomeres. Maybe individuals who have had their DNA examined in a wider medical context end up acquiring information about the length of their telomeres. In any case, I intend to carry on reading Dilbert comics in the hope of broadening my awareness of the marvels of modern medicine.

Friday, June 10, 2011

Gut bug villain identified

Germany has finally decided that bean sprouts are the source of the lethal strain of Escherichia coli.

But are German scientist well-informed and correct? After all the tergiversations, an observer of the devastating effects of Germany's outrageous Cucumbergate might have doubts.

In any case, it would be normal that Germany should pay cash for this erroneous rashness.

The notorious new strain of E. coli bacteria that came to light in Germany has caused acute diarrhea followed by a life-threatening affliction known as HUS (hemolytic-uremic syndrome), characterized by hemolytic anemia (breakdown of red blood cells) and acute uremia (kidney failure).

The designation of the deadly new strain, O104:H4, has nothing to do with the actual genome of this bacterium, which was sequenced in China at the BGI-Shenzhen laboratory. The O and H terms, designating the bacterium's serotype, refer to simple chemical substances called antigens that cover, respectively, the cell walls and tails of the bacteria, provoking defensive reactions (production of antibodies) from the immune system of the host in which the bacteria reside.

In fact, we humans have been living for ages with these terrifying E coli creatures, who've often become intimate friends. As the science-writer Robert Krulwich says so beautifully [click the bacteria images], they're our partners in the gigantic time-space adventure of existence, rather than our declared enemies, and we should respect them.

I nevertheless draw attention to a highly-pertinent document that I downloaded from the website of the University of California [find it by Google], suggesting that mungo bean seeds can be pathogenic, and that their inherent nastiness can move into sprouts in organic gardens. What more do we need to know or say?

ADDENDUM: This is a photo by Stew Milne for The New York Times. Click it to access an interesting US article on links between bean sprouts and the German bacterial outbreak. I learn that such events, in the USA, are referred to as sproutbreaks.

This fashionable foodstuff may indeed be most nutritious, and give the human consumer the pleasant sensation of being transformed into a herbivorous mammal (which we are not) akin to cows, horses and donkeys. What a pity that genetics in general, and bacteria in particular, don't have much respect for the latest nutritional fashions.

The Wikipedia article on the 2011 E. coli O104:H4 outbreak [display] is now well updated and informative... hopefully definitive.

Click the banner for an interesting and novel explanation of how the deadly bacteria might have set up home in our society.

Saturday, November 27, 2010

Nocturnal disturbance at Gamone

Once Fitzroy beds down for the night in his luxurious kennel, on a thick wad of sweet-smelling straw, he seems to sleep soundly. A couple of nights ago, exceptionally, he started to bark furiously around two o'clock in the morning. I opened the kitchen door so that Sophia could investigate. She has the advantage of seeing in the dark (I don't know how), whereas Fitzroy hasn't yet mastered that art. As for me, I looked around with a powerful flashlight, but I was unable to figure out what had woken up and disturbed Fitzroy.

The next morning, the two dogs were both in an aroused state, and barked frequently, as if a foreign presence were disturbing them.

I thought it might be the visiting pheasant, which I hadn't sighted for a couple of days. Or maybe it was a fox that had captured the pheasant. On the other hand, the direction of Sophia's muzzle suggested that the foreign presence might be located on the far side of Gamone Creek. Sure enough, I soon sighted a large roe deer. I even had time to race upstairs, fetch my Nikon, install a long-focus lens and take a couple of photos of the animal before it disappeared into the thicket.

For dogs, the scent of such an animal would seem to be both intense and alarming.

No sooner had I written the word "alarming" in the last sentence than I realized that it was quite stupid. But I won't remove it. My awareness of my mistaken use of this word illustrates the regular progress I'm making in becoming more and more naturally adapted to the evolutionary thinking of Richard Dawkins. The dogs are aroused by the scent of the deer for the simple reason that some of their archaic genes are screaming out (if genes can be thought of as capable of screaming) that the dogs should race out, attack this animal, kill it and eat its flesh. Wolves that reacted like that when they picked up the scent of deers ended up getting a good feed and surviving. On the other hand, wolves that didn't happen to get upset by the scent of deers were likely to starve, and die out instead of procreating. In other words, when little Fitzroy gets all adrenalized in the middle of the dark night, it's because his wolf genes are trying to persuade him that he should go out and capture a wild beast, to satisfy his hunger. But, insofar as Fitzroy's belly is already full of pasta and croquettes, his little dog's mind is puzzled about the logic of the signals being received from his muzzle and his archaic wolf genes. Ah, life is not necessarily easy when your closest ancestors were wild hungry wolves. It's easier for us humans because it's quite a long time since we dropped the habit of racing after deers in the middle of the night… if ever we behaved in such a way.

Once upon a time, I used to wonder how I might react if a glorious female creature were to sneak quietly into my bed while I was sound asleep, dreaming of Grecian nymphs. Would the powerful waves emitted by her presence react upon my archaic primate genes in such a way as to interrupt abruptly my snoring, and wake me up? Maybe they would. Maybe they wouldn't. To be perfectly honest, I've never had an opportunity of testing the experimental scenario I've just outlined. In any case, I'm sure as hell that I wouldn't start to bark or howl or race around crazily in the dark night. So, which of us males is better off, Fitzroy or me? It's hard to say...

BREAKING NEWS: Once again, at 2 o'clock in the middle of the night, Fitzroy spent half-an-hour barking. This morning, during our ritual walk up the road, the two dogs went out of their way to investigate scents in Gamone Creek up at the level of Bob's place, but without digging up anything. I've just been chatting with a hunter who strolled by with his dog, in the role of the advance scout (without a gun). He confirmed that there's a wild boar hiding in the creek up there, and that they plan to root him out later on in the day. So, we're promised a Wild West afternoon at Gamone, with gunshots, shouting and men and beasts scrambling down the slopes. I've often thought that what we need here at Choranche, particularly in the hunting season, is an elected sheriff. Meanwhile, with a wild boar in the neighborhood, the temporary winners are the roe deers and pheasants, which are considered by the hunters as relatively uninteresting small fry. Confronted by a terrified cornered boar, a hound can get its belly ripped open by the tusks of the beast. (Sophia and Fitzroy would scamper to safety before any such encounter.) The hunters no doubt appreciate this dimension of risk, and the aroma of blood. To my mind, it evokes bull-fighting accidents such as when a picador's horse is gored.

Saturday, August 28, 2010

British tribes

I've just been reading these two books, which tackle a fascinating subject: the genetic origins of the peoples of the British Isles.

Written by English authors—Stephen Oppenheimer and Bryan Sykes—both books were published in 2006. Curiously, each of the two authors gives the impression that he ignores the work of the other… even though they are both associated with the University of Oxford. They use both maternal (mitochondrial DNA) and paternal (Y-chromosome) data to reach their conclusions, which are rather similar. Basically, the people of Great Britain (England, Scotland and Wales) and Ireland are the descendants of settlers from the Iberian Peninsula (today's Spain and Portugal) who migrated up to the British Isles at the end of the Ice Age, some 15 millennia ago. In other words, our most ancient ancestors were the indigenous Cro-Magnons, rather than relatively recent colonists from the east. Among other things, this means that our indigenous European ancestors evolved spontaneously from being hunters and food-gatherers into the state of graziers and farmers. They were not simply replaced by eastern invaders who brought this know-how with them. As for legendary cultural phenomena such as the Celticism of the Gaelic-speaking lands, and the alleged Anglo-Saxon roots of the English, these must be thought of, genetically, as relatively-recent minor modifications, imported into the British Isles from the European continent, and limited largely to language.

I regret that both authors have resorted to nicknames for the various mtDNA and Y-chromosome haplogroups at the base of their vast research. For example, my personal DNA testing has placed me in a precise paternal haplogroup designated as R1b1b2a1b5. For Oppenheimer, on the other hand, I'm a member of the Ruisko tribe, which Sykes prefers to label the Oisin tribe. For serious adepts of DNA testing, the official haplogroup terminology is both necessary and sufficient, and the silly nicknames introduced by Oppenheimer and Sykes serve no useful purpose.

The existence of interesting in-depth studies such as those of Oppenheimer and Sykes evokes a common criticism that is often raised by people who are wary of the validity of all kinds of genealogical research, be it strictly personal (as when I explain with pride that my Skyvington patriarch in England came over with William the Conqueror, or that I've established another ancestral line running back up to this same Norman invader) or applied to the peoples of vast regions such as the British Isles. To get the gist of this criticism, look at the following pedigree chart (so-called because all the T-shaped signs can be imagined as goose tracks), in which my paternal ancestors are designated by blue dots, and my maternal ancestors by pink dots:

Now, it's all very well to determine the paternal tribe of the most ancient blue dot in our pedigree, and the maternal tribe of the earliest pink dot. But what about the respective tribes of the "infinite" (well, almost) horde of ancestors who aren't even apparent in my pedigree, let alone designated by any kind of dot? Surely, it's a grotesque over-simplification to allege that I belong to the Ruisko/Oisin tribe merely because of the blue dots in my pedigree. For example, let's imagine that one of my female ancestors happened to be a daughter of Boadicea, or that another had married Attila the Hun. Wouldn't perfectly-plausible family-history events such as these put a few gigantic flies in the ointment associated with the tidy little system of blue and pink dots? To put things in a more recent context, if I were suddenly to discover that one of my ancestors was a hitherto-unidentified offspring of Jack the Ripper, then my personal genetic package would owe no less to Jack and his clan than to any other distinguished tribe of Prehistory or Antiquity, and my inherited characteristics would certainly be more closely linked to those of the Ripper than to those of the Conqueror. Now, every serious researcher in genealogy should be perfectly aware of this common-sense situation. We describe the rare ancestral lines that we've been able to unearth, whereas we have nothing whatsoever to say (at least for the moment) about the vast network of untraced lines up into the mysterious past.

Getting back to the kind of research conducted by Oppenheimer and Sykes, isn't it a huge weakness to draw conclusions based merely upon the Y-chromosome and mtDNA profiles of present-day residents of the British Isles? If they had tested, say, a (fictive) London chap named George Skyvington and found that he (like me) was a descendant of the Ruisko/Oisin tribe, wouldn't they be drawing hasty and unsound conclusions by ignoring, as it were, that George might have had lots of other ancestors from quite remote tribes: Eskimos, American Red Indians, Chinese, Pacific Islanders, Tasmanian Aborigines, etc? Doesn't the absence of such perfectly-real ancestors cast a dark cloud of incompleteness or imperfection upon the global outcome of the research carried out by Oppenheimer and Sykes?

No, not at all. Don't forget that these researchers have been performing DNA tests upon large groups of people living in the British Isles. Consequently, if indeed our George Skyvington had ancestors belonging to "tribes" such as Eskimos, American Red Indians, etc, then it's possible that the existence of these ancestors will show up in the Y-chromosome and mtDNA data obtained from some of George's "genetic cousins"… about whom he probably knows nothing (and never will). Statistically, if the tested population is large enough (a criterion that can be determined mathematically), everything should come out in the wash, as it were. George's Eskimo and Red Indian ancestors won't be totally forgotten. They'll merely be associated with other tested individuals. And George won't even be tempted to complain about "his" ancestors being associated with total strangers, because he simply won't know that this has happened. Maybe George might even look at research results and say to himself: "My God, to think that, here in my native England, I'm living alongside descendants of Eskimos, American Red Indians, Chinese, Pacific Islanders, Tasmanian Aborigines, etc!"

Thursday, March 11, 2010

Scandinavian nuts and bolts

A recent article by Florence Williams in Slate [display] reveals apparent differences between Danish and Swedish males concerning the respective volumes of their genital resources.

Should the world at large be fascinated by this Swedish victory in the Prick and Balls Olympic event? The answer is no doubt yes. If things can shrivel up to such an extent between two neighboring nations, then we should try to understand what has happened... because the same sort of thing might just be happening in our own backyard, maybe even between neighbors with differing lifestyles. There's no smoke without a fire. So, there must be some set of underlying reasons why Swedes would appear to be getting it up better than Danes. It can't be the ambient climate, because it's much of a muchness. And it would be hard to imagine that cultural and lifestyle factors might account for this difference. There's no way in the world that you'll convince me that reading the delightful tales of Hans Christian Andersen, and eating Danish pastry, might have stealthily diminished the size of my John Thomas... and that the only way of getting things back to normal would consist of a strenuous acquaintance with the plays of August Swinberg and the films of Ingmar Bergman, combined with a massive daily intake of crisp bread and fermented fish, consumed in an Ikea environment.

Seriously: What exactly is it that might have influenced the respective qualities of the procreative devices of Danes and Swedes? That's an interesting question, but we don't yet know the answer. As they say in the classics, there will surely be a next episode...

Friday, February 19, 2010

Basques are not as bizarre as all that

When I first arrived in France, I was amused to find people advising me, apparently in a serious manner, that the best way by far to learn French was in bed. And that's how I soon became a serious language student. For a long time, in this spirit, I've had a theory that the ideal way in which to acquire a certain understanding, not only of a foreign language, but of peoples and even regions, is through a female friend who's associated with the language, land or region in question. In any case, that's the way the cookie has always crumbled for me personally. Inversely, I've often thought that one of the explanations (cause or rather an effect?) of my aloofness concerning both my native land and the USA, for example, is the sad fact that I've never, at any moment, been involved in a passionate relationship with an Australian or an American. [This is not a distressed call for help!]

Biarritz

The ancient Basque Country covers a tiny corner of Spain and an even tinier corner of south-west France, in the vicinity of the Bay of Biscay. I've never had an opportunity of visiting this region. On the other hand, I had a Basque girlfriend in Paris for several years and, through her, I've always felt a kind of solidarity (no doubt superficial) with the Basque region and culture. Besides, as soon as she started to talk about her last visit to her relatives in the vicinity of Biarritz, she would abandon her usual lighthearted conversational style and adopt an almost solemn tone, as if to inform me that there should be no joking about her beloved region. It would have been unthinkable for me to make a remark of any kind concerning notorious events that were mentioned regularly by the media: the activities in Spain and France of partisans of the creation of an autonomous Basque nation.


Many Australians have heard of Basque beaches where surfing competitions take place. The sport that is most readily associated with this people is Basque pelota, derived from the quaint old game of "royal tennis".

Over recent decades, many curious legends have been circulating on the subject of the Basque people, who are often considered as a unique biological family, who might even be direct descendants of Cro-Magnon man. These legends probably came into existence initially because of the mysterious Basque language, which is indeed unique. It does not belong to the vast group of so-called Indo-European languages, and it appears to be unrelated to any other language in the world. Then, when blood tests appeared on the scene, it was found that 20 percent of Basques are Rh negative, as compared to only 15 percent among the English, and 3 percent among the Chinese. Even the great pioneer of population genetics Luigi Luca Cavalli-Sforza still looks upon this fact as evidence in favor of the Cro-Magnon hypothesis.

DNA testing then stepped into this arena, and it has clarified our ideas, and even changed them in many ways. Two days ago, a major article on the Basque question was published online [display]. It reveals that "a genome-wide survey does not show the genetic distinctiveness of Basques", who cannot be considered a genetic outsider. The authors of the article conclude that "interpretations on their origin may have to be revised". Now, I'm not sure that my former girlfriend would be happy to learn that there's nothing special about the Basques.

Much current research into the origins of Europeans concerns the famous R1b1b2 haplogroup, which is widespread throughout Europe. [I myself belong to the R1b1b2a1b5 subgroup, designated since the end of 2008 as the R-L21 family, with our own website.] Now, it has been known for quite a while that most Basques belong to this R1b1b2 haplogroup. The big question facing population geneticists has been this: What were the relative contributions to modern European populations of Paleolithic hunter-gatherers and Neolithic farmers from the Middle East? In other words, were our ancestors basically Old Stone Age hunter-gatherers who finally transformed their way of life when they heard about the possibility of becoming farmers? Or were our ancestors New Stone Age farmers who migrated to Europe, maybe only 10,000 years ago, from their Middle Eastern lands of origin? The answer seems to be that there was an equivalent dosage of both these origins. But in all cases, Y-chromosome research indicates that the origin of the Basques was no different to that of other Europeans.

So, how do specialists explain the Rh negative phenomenon? Well, it now appears that blood groups are not a trustworthy standard in population genetics, since they can be influenced, over the centuries, by the spread of diseases. And how do linguists explain the strange Basque language? For the moment, they can't...

Sunday, February 14, 2010

Inuk the Eskimo

It's truly fantastic to hear that scientists have used a specimen of permafrost-preserved hair to sequence the genome of a male, known henceforth as Inuk, who lived in Greenland some 4,000 years ago.

This feat was performed under the direction of two Danish geneticists, Morten Rasmussen and Eske Willerslev, and their results were confirmed by laboratories throughout the planet... including a DNA laboratory at Murdoch University in Perth and an Australian police laboratory in Canberra.

The basic article concerning this achievement, entitled Ancient human genome sequence of an extinct Palaeo-Eskimo, appeared in the journal Nature. [Click the banner to access the article.]

Inuk's paternal haplogroup is designated as Q1a, which characterizes peoples who migrated from Siberia into the New World some 5,500 years ago. He belonged to a cultural group called the Saqqaq. Funnily, this means that Inuk does not belong to the same family as modern Inuit populations. To obtain their spectacular results, the researchers had to identify over a third of a million SNPs (single-nucleotide polymorphisms, called "snips"). The most amazing aspect of these findings is that Inuk's genome provides the researchers with a lot of interesting facts about this man's physical features:

— His blood type was A+.

— He probably had brown eyes.

— His skin and hair were probably rather dark. Besides, he would have normally become bald at an early age.

— He probably had front teeth of a form designated as "shovel-graded".

— His earwax was probably of a dry kind, like that of Asians and Native Americans (as distinct from the wet earwax of other ethnic groups).

It's amusing to learn that, since none of the institutions involved in this project employ Saqqaq descendants, the chances of errors due to DNA contamination from laboratory assistants were practically zero.

In my recent article entitled Nativity rites [display], I made a plea in favor of the systematic DNA-testing of babies. My old friend Odile phoned me the next day to tell me that she thought I had "blown a fuse"... which suggests that many people still regard DNA-testing as a weird operation. No, I persist and sign this idea— which is not at all crazy—of nativity rites of a new kind, based upon a DNA record for the newborn child. When we observe the fascinating facts that can be gleaned from a DNA specimen that dates from four millennia ago, it becomes obvious that we should encourage the generalized registration of such fabulous individual "blueprints".

Friday, February 5, 2010

Nativity rites

Jean Sarkozy, the president's son, married his adolescent sweetheart, Jessica Sebaoun-Darty. The following photo shows the father and the son, accompanied by their respective wives.

A son, Solal, was born to Jessica and Jean on 13 January 2010. A few days ago, I saw in the press that the baby was subjected to the Jewish tradition of circumcision, which I find archaic and physically revolting. The Christian rite of baptism is less bloody, but just as stupid today, at the start of the third millennium. In both cases, an innocent child is being enthroned as a member of an elite body of religious believers, and this membership is being established solemnly at a time when the tiny creature at the heart of the ceremony is not yet capable of any degree of intellectual discernment. What utter nonsense, perpetrated by mindless adults!

In a recent article entitled Little gods [display], I mentioned my reading a book by the great atheist author Christopher Hitchens. On the question of circumcision, I was moved by the parts of that book in which Hitchens condemns "child abuse" in the form of "sexual mutilation". He even gives us the gory details of the way in which circumcision has been performed, as recently as 2005 in New York, by certain Hasidic fundamentalist foreskin-removers. Nasty stuff!

I predict a day in the not-too-distant future when a joyful nativity rite of a new non-religious kind will become, as it were, standard practice. The DNA of the newly-born individual will be examined and stored permanently (as permanently as possible) in a great database of the kind that would bring joy to the heart of a Mormon genealogist. And this rite would symbolize (literally, you might say, since the DNA sample is in fact a huge set of symbols) the baby's passage into the great planetary congregation of humanity.

For the moment, those who come closest to this nativity rite are the researchers in genealogy who get their DNA tested (like me). But it remains a relatively superficial affair, since only the Y-chromosome of males and the mitochondrial DNA of females are in fact examined. And it's a private firm that holds on to the DNA samples. So, I can't really count upon the hope—if ever that were my intention (which it isn't)—of my being cloned at some future time.

No sooner had I finished writing this article than I came upon a CNN story [click the baby photo to display it] indicating that US babies appear to have their DNA tested systematically, with medical reasons in mind... much to the distress of certain parents.

Insofar as humans seem to like ceremonies based upon rites of passage of various kinds (birth, marriage, death, etc), I can well imagine creative Americans (the sort of people who have transformed Halloween into a planetary event) who would find ways of transforming the baby's DNA test into a kind of celebration, with music, food and drinks, solemn speeches and even short readings from the books of Dawkins, performed by students of genetics. This new nativity rite could be called DNAtion (rhymes with creation, confirmation and ordination).

Thursday, December 31, 2009

Ray of hope for our devils

For many years, the marsupial known as the Tasmanian devil has been the victim of a terrible form of facial cancer that is so contagious that it could well drive these precious creatures to extinction.

An article in The New York Times reveals the existence of a ray of hope [display]. It has always saddened my heart to hear that these fabulous beats have been suffering and dying, and it would be utterly marvelous if modern genetics could save them.

In another cancer domain, concerning human beings, scientists at the UK-based Wellcome Trust Sanger Institute have catalogued the genetic maps of skin and lung cancer, and identified specific DNA mutations that can lead to malignant tumors.

There's something beautifully harmonious in the idea that we humans and the Tasmanian devils are all awaiting the magic benefits of scientific research. There's no sense in our praying, of course, since devils—like atheists—don't seek salvation from God.

Thursday, October 22, 2009

Warming my toes with Darwin & Dawkins

When Badger suggests, in a comment to my First fire article [display], that I might be curling up my toes in front of the fireplace instead of pursuing Antipodes, he has hit the proverbial nail on its head. I have indeed got into the pleasant habit, over the last week, of sitting in front of the fire of an evening and soaking in slowly—as if I were appreciating a fine wine—the powerful words of the Richard Dawkins book that I evoked recently in the article entitled Latest Dawkins book [display]. I found it hard to imagine a priori that Dawkins still had room to produce yet another book on his usual themes of Darwinism and genes, but all I can say is that the master has succeeded brilliantly, surprising me in ways that I would never have imagined.

Insofar as this book simply aims to supply readers with the actual evidence in favor of Darwinian evolution, Dawkins has written it in an almost colloquial style. Here's a humorous specimen: One Australian river turtle, indeed, gets the majority of its oxygen by breathing (as an Australian would not hesitate to say) through its arse.

There's a hell of a lot of good basic stuff about fossils and the way in which they're dated by radioactive "clocks". I don't know whether or not God exists, but the Devil surely does... otherwise I can think of no other reason to explain why Ardi waited up until the Dawkins book had just rolled off the press before making her coming-out. In a way, it's no sweat, because (a) it's easy to fit Ardi into the context presented by Dawkins; (b) it's nice for us lowly disciples to have an opportunity of feeling, if only for a short while, that we possess more information than the master; and (c) we'll be looking forward to a forthcoming book in which Dawkins will give us his reactions to Ardi.

To my mind, the best-written section of this book deals with embryology, and a quasi-magical phenomenon known as epigenesis, which concerns the processes enabling a single cell to "evolve" (nothing whatsoever to do with Darwinian evolution) into a living organism. We know that the single cell soon splits exponentially into countless essentially identical cells. But how do all these cells get their act together in such a way as to coalesce into a creature such as a dog or a human, or a rose bush? If we liken the end product (the creature or the plant) to a symphony performed buy an orchestra, and the cells to a vast set of musicians belonging to the orchestra, where's the conductor who makes sure that every performer is playing the required notes in a perfect manner? For that matter, where's the score? To approach such questions, Dawkins resorts to the fabulous metaphor of flocks of starlings in an aerial ballet:



The amazing conclusion is that each cell in the evolving organism, like each starling in the flock, is in fact doing its own thing. There is neither an explicit score, nor a unique conductor. This idea is hard to grasp. Computer programmers are accustomed to working in the domain of object-oriented programming, where you program a single relatively-simple object equipped with its own methods, whereupon you can instantiate that object as many times as you like, with differing parameters. This computer-based version of cloning provides a good paradigm of the starling phenomenon, or the process that enables ants to build vast and complex subterranean cities. And this is what biological epigenesis is all about.

Everybody knows that DNA can be likened to a string. But living tissues are highly-convoluted three-dimensional structures. So, in embryology, how do simple strings get folded into all the wonderful shapes of living creatures and plants? To tackle this question, Dawkins calls upon the metaphor of paper-folding, known as origami, of which there are many fascinating demonstrations on YouTube [click here for an origami rose].

The only negative element in this great new Dawkins book is his insertion of a four-page transcription of a TV interview between Dawkins and a female named Peggy Wright, president of Concerned Women for America. In the context of so much scientific poetry and wisdom, her presence is like a hair in the soup. Read the book, to see if you agree/disagree with me.

Saturday, July 4, 2009

Snippets and stutters

My title is a fanciful allusion to the two basic entities used in the fascinating domain of family-history research based upon DNA, which has interested me now for several months. There are so many novel concepts and bits of necessary know-how in this field that I've started to set them down in the form of a text, which might one day be of use to other newcomers.

The first thing you discover about this exciting new genealogical tool is that there are two quite different approaches:

-- A female can have her DNA tested to learn about her matriarchal line: that's to say, her mother, her mother's mother, the mother of her mother's mother, and so on. This testing uses mitochondrial DNA, designated in short as mtDNA.

-- A male can have his mtDNA tested in exactly the same way, and the results will be identical to those of his sisters. A male can also have his Y-chromosome tested, to learn about his father, his father's father, the father of his father's father, and so on.

Since a female researcher doesn't have Y-chromosomes, she can't be tested in this second way. But that's not a problem as long as she can call upon either her father, a brother or some other male relative on her paternal side to obtain such Y-chromosome information.

For the moment, personally, I've been tested only at this second level. The results are directly linked to the ancient origins of the Skyvington surname, which is currently being documented.

Let me explain rapidly the sense of my blog title:

-- In a strand of DNA, in a so-called junk region of the molecule (lying outside the coded sections that determine our nature), it can happen that a single letter is suddenly and mysteriously misspelled. For example, a meaningless "word" that has been spelled CAT since time immemorial suddenly reappears, in the DNA of an offspring, with a spelling error: say CGT. An error of this kind is called a single-nucleotide polymorphism [SNP, pronounced snip]. Now, this kind of mutation is extremely rare, but once such a mispelling occurs, the error is reproduced forever after. Some 16 to 18 millennia ago, there was a famous Y-chromosome snip referred to as M343, and one of the fellows with this trivial spelling error in his junk DNA happened to become the great-granddaddy of all of us western Europeans. So, if you find this M343 snip in your DNA, you can be fairly sure that some of your paternal ancestors once spent some time in western Europe.

-- In a strand of DNA, something akin to stuttering takes place when a tiny fragment is repeated several times, for no apparent reason. In a certain individual, a specific instance of such stuttering might involve, say, 14 repetitions, whereas another person might have a count of 13 or maybe 15. This stuttering is called short tandem repeats [STR, pronounced by naming separately each of the three letters: ess-tee-ahr]. Whenever the number of repeats is augmented (suddenly and mysteriously, as for snips, but far more often), the new value is reproduced in descendants of the mutated individual.

Let's leave things there for the moment, because I don't necessarily intend that Antipodes should be transformed into a series of biology lessons. But I'll return rapidly to these subjects, because I've been learning a lot of interesting things, over the last few days, about my paternal snippets and stutters.

Wednesday, May 20, 2009

Our concestor Ida

Like countless Earth-dwellers, I was moved by the fabulously beautiful image of our concestor Ida.

Even Google got into the act immediately, which proves (if need be) that the discovery and presentation of the fossil is a cosmic happening:

The term "concestor" was introduced into the terminology of tribal history (or genealogy, if you prefer) by Richard Dawkins in his monumental The Ancestor's Tale. It stands for "the (latest) common ancestor". For example, when a Skyvington in Choranche encounters, say, an individual named Skivington over in Canada, it's quite possible that their concestor was a 17th-century farmer named George over in Dorset, England. Researchers concerned with individuals X and Y are interested, above all, in identifying the latest concestor: that's to say, the common ancestor whose offspring split into two forever-separate lines, one of which ended up producing X, and the other, Y.

Juvenile Ida ("lovely Laura in her light green dress") looks a little like a modern lemur:

Let's say that 47-million-year-old Ida was almost a lemur... like our human ancestors, for that matter. But certain telltale features reveal that Ida had jumped onto the human, rather than the lemur, band wagon. She was surely one of us: an ancient member of our human tribe. Welcome aboard, Ida!

Thursday, April 16, 2009

My DNA data

I guess I could say that this is the first official certificate I've ever received from an American institution. And I didn't even have to do any hard work to obtain it. Now, this is terribly personal information, like the image of my skull in one of my early blog articles [display], which greatly disturbed my longtime friend Odile. But there's no personal copyright attached to my DNA certificate, and I wouldn't mind at all if this data were to get stolen by all kinds of hackers and scientists with secret plans to clone me.

The Texan folk who tested me have also supplied a nice little map showing how my ancestors moved away from the territory of our African patriarch known as Adam, and finally ended up here in France... where members of the family were called Cro-Magnon long before they got around to adopting a nicer surname, Skyvington. Without wishing to appear snobbish, I'm happy they made that name change, because Cro-Magnons were as common, back at that time, as today's Smiths and Duponts.

My folk are indicated by the arrow marked R1b, which means that they followed a long trail through central Asia before getting here. In fact, it's a mere 25 millennia since they moved away from the territory marked R, located in the vicinity of modern Kazakhstan, and set off westwards towards Europe.

For the moment, I haven't found any genetic cousins (individuals with exactly the same marker values) with a surname like mine, but I'm trying to persuade various Skivington and Skeffington men throughout the world to get tested. This genetic genealogy adventure will be followed up in my specialized Skeffington Genealogy blog [display] whose banner appears in the right-hand column of the present blog. At an anecdotal level, I've mentioned there that I was proud to learn that Richard Dawkins happens to be one of my genetic cousins.